Rv deshpande biography of martin luther king
•
Profile
- Clinical Assistant Professor in Oral and Maxillofacial Surgery
口腔頜面外科臨床助理教授
- Computer-assisted surgery
- Oral cancer
- Jaw reconstruction
- Pu Jane J., Yu Xingna, Pow Edmond H.N., Lam Walter Y.H., Su Yu-Xiong. Single-Double-Single Barrel () Fibula Free Flap Design for Functional and Esthetic Brown Class III Mandibular Reconstruction , Plastic and Reconstructive Surgery ; doi/PRS
- Callahan Nicholas, Pu Jane Jingya, Su Yu-Xiong Richard, Zbarsky Steven JD, Weyh Ashleigh, Viet Chi T. Benefits and Controversies of Midface and Maxillary Reconstruction, Atlas of The Oral and Maxillofacial Surgery Clinics of North America ; doi/
- Pu Jingya Jane, Choi Wing Shan, Wong May CM, Wu Songying, Leung Pui Hang, Yang Wei-fa, Su Yu-Xiong. Long-term stability of jaw reconstruction with microvascular bone flaps: A prospective longitudinal study, Oral Oncology ; doi/cology
- Pu Jingya Jane, Su Yu-xiong. Response to comments to “Long-term stability of jaw reconstruction with microvascular bone flaps: A prospective longitudinal study”, Oral Oncology ; doi/cology
- Pu Jingya, Chang Tommy, Su Yuxiong. End-to-Side Cross-face Nerve Graft for Mental Nerve Reconstruction after Segmental Mandibulectomy, Plastic and Reconstructive Surgery ;
Article
•
Summary
Although adult subependymal zone (SEZ) neural stem cells mostly generate GABAergic interneurons, a small progenitor population expresses the proneural gene Neurog2 and produces glutamatergic neurons. Here, we determined whether Neurog2 could respecify SEZ neural stem cells and their progeny toward a glutamatergic fate. Retrovirus-mediated expression of Neurog2 induced the glutamatergic lineage markers TBR2 and TBR1 in cultured SEZ progenitors, which differentiated into functional glutamatergic neurons. Likewise, Neurog2-transduced SEZ progenitors acquired glutamatergic neuron hallmarks in vivo. Intriguingly, they failed to migrate toward the olfactory bulb and instead differentiated within the SEZ or the adjacent striatum, where they received connections from local neurons, as indicated by rabies virus-mediated monosynaptic tracing. In contrast, lentivirus-mediated expression of Neurog2 failed to reprogram early SEZ neurons, which maintained GABAergic identity and migrated to the olfactory bulb. Our data show that NEUROG2 can program SEZ progenitors toward a glutamatergic identity but fails to reprogram their neuronal progeny.
Keywords: adult neurogenesis, neural specification, neural stem cell, neurogenin 2, adult subventricular zone, olfactory bulb, f
•